Description

Okadaic Acid Ammonium Salt, 98 CAS NO 175522-42-6 is a high-purity, cell-permeable inhibitor of protein phosphatases PP1 and PP2A. This compound is a critical research tool for studying cellular signaling pathways, protein phosphorylation, and the mechanisms of tumor promotion. It is essential for researchers and scientists in the fields of biochemistry, molecular biology, and toxicology, particularly for investigating signal transduction, cell cycle regulation, and the effects of marine toxins.

Application

• Biochemical Research: As a potent and selective inhibitor of serine/threonine protein phosphatases PP1 and PP2A for studying phosphorylation-dependent signaling cascades.
• Cell Biology Studies: Used to induce hyperphosphorylation of proteins in cell culture models to investigate cell cycle control, apoptosis, and cytoskeletal dynamics.
• Toxicology & Marine Biotoxin Research: Serves as a reference standard and active agent for studying diarrhetic shellfish poisoning (DSP) and the effects of algal toxins.
• Pharmaceutical Development: Employed in target validation and mechanistic studies for diseases where protein phosphatase activity is dysregulated, such as cancer and neurodegenerative disorders.
• Diagnostic Kit Manufacturing: Used as a key component in the development of enzyme activity assays and test kits for phosphatase inhibition screening.

Basic Information

Product Name	Okadaic Acid Ammonium Salt, 98
CAS No.	175522-42-6
Molecular Formula	C44H68NO13 • xNH3
Molecular Weight	~805.0 g/mol (Free acid: 805.0)
Synonyms	Okadaic Acid Ammonium Salt; Okadaic Acid NH4 Salt; OA Ammonium Salt; PP1/PP2A Inhibitor; 1H-Benz[cd]indol-2-ol, 1,3,4,5,6,7,9,10,11,11a-decah- ydro-7,14-dihydroxy-10-[(1S)-1-hydroxyethyl]-2,6,10-trimethyl-4-oxo-4H-pyrano[3,2-a]phenoxazin-9-yl 6-deoxy-2,3-di-O-methyl-α-L-mannopyranoside, ammonium salt; Diarrhetic Shellfish Poison (DSP) Toxin Standard.
EINECS	Contact for details

Quality Control

Our Okadaic Acid Ammonium Salt is produced and tested under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and solvent content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (PP2A Inhibition IC50)	≤ 1.0 nM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.