Description

4-Bromo-2-Ethylbenzene-1-Sulfonyl Chloride is a versatile and highly reactive organosulfur compound primarily used as a key synthetic intermediate. Its value lies in its dual functionality, featuring both a sulfonyl chloride group for nucleophilic substitution and a bromo substituent for cross-coupling reactions, enabling the construction of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a critical building block for active pharmaceutical ingredients (APIs), functional ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct bioactive molecules for crop protection agents, such as herbicides and fungicides.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and functionalized surfaces.
• Chemical Research: A valuable reagent in medicinal chemistry and process R&D for introducing the sulfonyl moiety into target molecules.
• Ligand Preparation: Employed in the synthesis of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke fine chemicals.

Basic Information

Product Name	4-Bromo-2-Ethylbenzene-1-Sulfonyl Chloride
CAS No.	175278-24-7
Molecular Formula	C8H8BrClO2S
Molecular Weight	283.57 g/mol
Synonyms	4-Bromo-2-ethylbenzenesulfonyl chloride; 2-Ethyl-4-bromobenzenesulfonyl chloride; 1-Bromo-3-ethyl-4-chlorosulfonylbenzene; Benzenesulfonyl chloride, 4-bromo-2-ethyl-; 175278-24-7; 4-Bromo-2-ethyl-1-benzenesulfonyl chloride; 4-Bromo-o-ethylbenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Ethylbenzene-1-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator to prevent hydrolysis of the sulfonyl chloride group. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.