Description

4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in the reactive sulfonyl chloride group, which enables efficient introduction of the sulfonyl moiety, and the strategically placed bromo and trifluoromethoxy substituents, which impart unique electronic and steric properties to target molecules. This compound is primarily needed by R&D and process development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of sulfonyl derivatives.
• Material Science Research: Serves as a precursor for functionalized monomers or additives in specialty polymers and advanced materials.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination for further diversification.
• Ligand and Catalyst Development: Utilized in the preparation of complex ligands for catalysis or molecular recognition studies.
• Chemical Biology Probes: Acts as a starting material for synthesizing activity-based probes or affinity labels to study protein function.

Basic Information

Item	Detail
Product Name	4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride
CAS No.	175278-14-5
Molecular Formula	C7H3BrClF3O3S
Molecular Weight	339.51 g/mol
Synonyms	1-Bromo-4-(trifluoromethoxy)benzene-2-sulfonyl chloride; 4-Bromo-2-(trifluoromethoxy)benzenesulfonyl chloride; 2-(Trifluoromethoxy)-4-bromobenzenesulfonyl chloride; 4-Bromo-alpha,alpha,α-trifluoro-2-methoxybenzenesulfonyl chloride; 4-Bromo-2-trifluoromethoxybenzenesulfonyl chloride; 4-Bromo-2-(trifluoromethoxy)phenylsulfonyl chloride; 1-Bromo-4-trifluoromethoxy-2-benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.