Description

4-(Trifluoromethyl)Pyridine-3-Carboxylic Acid Hydrazide is a high-value trifluoromethylated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique structure, combining a pyridine core with a trifluoromethyl group and a reactive hydrazide moiety, makes it indispensable for creating novel compounds with enhanced properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-3-Carboxylic Acid Hydrazide
CAS No.	175204-84-9
Molecular Formula	C7H6F3N3O
Molecular Weight	205.14 g/mol
Synonyms	4-(Trifluoromethyl)nicotinic acid hydrazide; 3-Pyridinecarboxylic acid, 4-(trifluoromethyl)-, hydrazide; 4-Trifluoromethylnicotinic hydrazide; Nicotinic acid, 4-(trifluoromethyl)-, hydrazide; 4-(Trifluoromethyl)nicotinohydrazide
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-3-Carboxylic Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.