Description

Reversin 205 is a high-purity, non-competitive P-glycoprotein (P-gp) inhibitor used in biochemical and pharmacological research. This compound is critical for studying multidrug resistance (MDR) mechanisms in cancer cells and for enhancing the intracellular accumulation of various chemotherapeutic agents. It is an essential research tool for scientists and laboratories in the fields of oncology, pharmacology, and drug discovery, where precise modulation of efflux transporters is required.

Application

• Research on multidrug resistance (MDR) reversal in cancer cell lines.
• Inhibition of P-glycoprotein (P-gp) efflux pump activity in in vitro assays.
• Enhancement of intracellular uptake and efficacy of chemotherapeutic drugs like doxorubicin and paclitaxel.
• Mechanistic studies in membrane transporter biology and pharmacokinetics.
• Tool compound for high-throughput screening in drug discovery programs.
• Use in academic and industrial research to investigate drug-drug interactions.

Basic Information

Product Name	Reversin 205
CAS No.	174630-05-8
Molecular Formula	C₂₈H₄₀N₄O₅
Molecular Weight	512.65 g/mol
Synonyms	N-(2-(4-(2,6-Dimethyl-4-(3-methylbut-2-en-1-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-N-methyl-2-(naphthalen-1-yloxy)acetamide; Reversin-205; NSC 73306; P-Glycoprotein Inhibitor Reversin 205; Multidrug Resistance Reverser 205
EINECS	Contact for details

Quality Control

Our Reversin 205 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.