Description

Glyoxalase I Inhibitor (Free Base) CAS NO 174568-92-4 is a potent and selective small molecule inhibitor of the glyoxalase I enzyme, a key target in metabolic and oncological research. This compound is crucial for studying the methylglyoxal detoxification pathway, which is implicated in diabetic complications, cancer cell survival, and advanced glycation end-product (AGE) formation. It is an essential research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on metabolic disorders, oncology, and anti-aging therapeutics.

Application

• Biochemical Research: Used as a specific probe to inhibit glyoxalase I activity in cell-based and enzymatic assays to study the glyoxalase system.
• Oncology Research: Investigated for its potential to induce cytotoxicity in cancer cells by disrupting methylglyoxal metabolism and promoting apoptosis.
• Metabolic Disease Studies: Applied in research models of diabetes to understand the role of methylglyoxal in diabetic complications like neuropathy and nephropathy.
• Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening campaigns for developing novel glyoxalase I inhibitors.
• Academic Research: Utilized in universities and research institutes for fundamental studies on oxidative stress, glycation, and cellular detoxification pathways.
• AGE Formation Inhibition Studies: Employed to research mechanisms for inhibiting the formation of advanced glycation end-products, relevant to aging and chronic diseases.

Basic Information

Product Name	Glyoxalase I Inhibitor (Free Base)
CAS No.	174568-92-4
Molecular Formula	C15H12N2O4S
Molecular Weight	316.33 g/mol
Synonyms	S-(p-Bromobenzyl)glutathione Cyclopentyl Diester; TLSC702; Glyoxalase I Inhibitor; GLO1 Inhibitor; (1S,5R,6S)-6-[(2S)-2-[[(2R)-2-Amino-3-(4-bromophenyl)sulfanyl-propanoyl]amino]-3-(cyclopentyloxy)-3-oxo-propyl]-7-oxabicyclo[3.2.0]heptane-2,3-dione; Glutathione Analog Inhibitor; Bromobenzylglutathione Cyclopentyl Diester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Glyoxalase I Inhibitor (Free Base) is characterized using advanced analytical techniques to guarantee identity, purity, and stability. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.