Description

4-(Trifluoromethyl)Pyridine-2-Sulfonyl Chloride is a high-value organosulfur and heterocyclic building block characterized by its reactive sulfonyl chloride group and electron-deficient pyridine core. This compound is critically important for introducing the 4-(trifluoromethyl)pyridine-2-sulfonyl moiety into target molecules, enabling the development of advanced materials and bioactive agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel compounds.

Application

The primary utility of 4-(Trifluoromethyl)Pyridine-2-Sulfonyl Chloride lies in its role as a versatile sulfonylation reagent. Its applications include:

• Pharmaceutical Intermediates: Key building block for the synthesis of sulfonamide-based drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that leverage the metabolic stability imparted by the trifluoromethyl and sulfonamide groups.
• Material Science Precursors: Serves as a monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Chemical Biology Probes: Employed in the design of activity-based probes and covalent inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-2-Sulfonyl Chloride
CAS No.	174485-71-3
Molecular Formula	C6H3ClF3NO2S
Molecular Weight	245.61 g/mol
Synonyms	2-Pyridinesulfonyl chloride, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2-pyridinesulfonyl chloride; 4-Trifluoromethylpyridine-2-sulfonyl chloride; 4-(Trifluoromethyl)pyridine-2-sulfonyl chloride; 2,4-Pyridinedicarboxylic acid, 5-(trifluoromethyl)-, 2-(chlorosulfonyl)-; 174485-71-3
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and moisture content analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and moisture-sensitive nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.