Description

4-[n-Maleimidomethyl]Cyclohexane-1-Carboxylhydrazide Hcl 1/2 Dioxane is a high-purity heterobifunctional crosslinking agent, specifically designed for the stable conjugation of biomolecules. Its core value lies in providing a reliable and efficient link between amine-containing and sulfhydryl-containing compounds, forming stable thioether bonds. This product is essential for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and advanced pharmaceutical research, where precise and robust molecular assembly is critical.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: A key reagent for covalently attaching cytotoxic payloads to monoclonal antibodies via amine and thiol groups.
• Protein and Peptide Labeling: Used for site-specific modification of proteins, enabling the attachment of fluorophores, enzymes, or other probes for diagnostics and imaging.
• Surface Immobilization: Functionalizing solid supports (e.g., beads, chips, plates) for creating biosensors or affinity purification matrices.
• Polymer Modification: Introducing reactive maleimide groups into polymer backbones for subsequent conjugation with thiolated molecules.
• Biomaterial Engineering: Crosslinking hydrogels or other biomaterials to incorporate bioactive peptides or proteins.
• Diagnostic Assay Development: Conjugating enzymes or other signal-generating molecules to antibodies or antigens in immunoassays.

Basic Information

Product Name	4-[n-Maleimidomethyl]Cyclohexane-1-Carboxylhydrazide Hcl 1/2 Dioxane
CAS No.	174422-72-1
Molecular Formula	C13H20N4O4 • HCl • 0.5 C4H8O2
Molecular Weight	Contact for details
Synonyms	4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid hydrazide hydrochloride dioxane adduct; MCC-Hz•HCl•0.5 Dioxane; SMCC Hydrazide Hydrochloride Dioxane Solvate; 4-(Maleimidomethyl)cyclohexanecarboxylic Acid Hydrazide HCl Dioxane Complex; (4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carbonyl)hydrazine hydrochloride dioxane solvate; Maleimidomethylcyclohexanecarboxylhydrazide HCl Dioxane; Heterobifunctional Crosslinker SMCC-Hz HCl Dioxane
EINECS	Contact for details

Quality Control

Our 4-[n-Maleimidomethyl]Cyclohexane-1-Carboxylhydrazide Hcl 1/2 Dioxane is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and solvent content. We adhere to high standards suitable for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Solvent Content (NMR/KF)	Dioxane content as specified
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.