Description

Ac-Yvad-Cho CAS NO 174063-88-8 is a high-purity, synthetic peptide inhibitor of caspase-1, also known as interleukin-1β converting enzyme (ICE). This compound is a critical research tool for studying the mechanisms of apoptosis and inflammation, particularly in the context of neurodegenerative diseases and immune responses. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on inflammatory pathways and cell death.

Application

• Biochemical Research: A selective and potent inhibitor for caspase-1/ICE in enzymatic assays and cell-based studies.
• Pharmaceutical Development: Used in target validation and screening for novel anti-inflammatory and neuroprotective drug candidates.
• Apoptosis Studies: Key reagent for investigating programmed cell death pathways in various disease models, including ischemia and neurodegeneration.
• Inflammation Research: Tool compound for elucidating the role of interleukin-1β maturation and secretion in inflammatory disorders.
• Academic & Institutional Labs: Standard reagent for graduate and post-doctoral research in cell biology and immunology.
• Biotech Production: May be used in process development and quality control for biologics targeting inflammatory cytokines.

Basic Information

Product Name	Ac-Yvad-Cho CAS NO 174063-88-8
CAS No.	174063-88-8
Molecular Formula	C₂₀H₂₉N₅O₆
Molecular Weight	435.48 g/mol
Synonyms	Ac-Tyr-Val-Ala-Asp-CHO; Ac-YVAD-CHO; Acetyl-Tyr-Val-Ala-Asp-al; Caspase-1 Inhibitor, Ac-YVAD-CHO; ICE Inhibitor II; Interleukin-1β Converting Enzyme Inhibitor II; N-Acetyl-L-tyrosyl-N-[(2S,3S)-3-formyl-1-[[(2S)-1-hydroxy-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-L-alaninamide; N-Acetyl-L-Tyr-L-Val-L-Ala-L-Asp-al
EINECS	Contact for details

Quality Control

Our Ac-Yvad-Cho is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.