Description

Demethyldolastin 10 Hydrochloride is a high-purity synthetic compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis and study of novel therapeutic agents, particularly in oncology. It is essential for research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the discovery and production of innovative drug candidates. The material is supplied with a focus on consistency and reliability to meet the stringent demands of modern chemical and biological research.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly in oncology research.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate biological activity and mechanism of action.
• Process Development: Serves as a critical material for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Academic Research: Utilized by universities and research institutes for fundamental studies in medicinal chemistry and pharmacology.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Demethyldolastin 10 Hydrochloride
CAS No.	173441-26-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Dolastatin 10, Demethyl; Demethyl Dolastatin 10 HCl; (2S,3R,5S,7aS)-3-[(2S)-2-Amino-3-phenylpropanoyl]amino-2-hydroxy-7a-methyl-1,2,3,5,6,7-hexahydropyrrolizin-5-yl (2S)-2-amino-3-phenylpropanoate hydrochloride; LU-103793 (Hydrochloride); NSC-696854; Cemadotin Hydrochloride (related analog).
EINECS	Contact for details

Quality Control

Our Demethyldolastin 10 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and tests for residual solvents and moisture content. We provide full traceability and a Certificate of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment ensures the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.