Description

4-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenethoxy)Quinazoline is a specialized photolabile chemical building block featuring a trifluoromethyl-diazirine moiety. This compound is of significant value for its ability to act as a photoaffinity labeling agent, enabling the study of biomolecular interactions and binding sites. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for advanced proteomics, drug discovery, and chemical biology applications.

Application

• Photoaffinity Labeling (PAL): A critical tool for covalently capturing transient or weak protein-ligand interactions upon photoactivation with UV light.
• Proteomics & Target Identification: Used to identify and characterize unknown protein targets for bioactive small molecules in drug discovery pipelines.
• Chemical Biology Probes: Serves as a core component in the synthesis of activity-based probes for mapping enzyme active sites and profiling protein function.
• Structural Biology Studies: Facilitates the elucidation of binding pockets and interaction mechanisms through cross-linking mass spectrometry.
• Bioconjugation & Material Science: Employed to create photo-crosslinkable surfaces or materials for biosensor development and biomaterial engineering.

Basic Information

Product Name	4-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenethoxy)Quinazoline
CAS No.	173219-33-5
Molecular Formula	C20H15F3N4O
Molecular Weight	384.36 g/mol
Synonyms	4-[2-[4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenoxy]ethyl]quinazoline; 4-(4-(3-(Trifluoromethyl)diazirin-3-yl)phenethoxy)quinazoline; TPD-Q; Quinazoline-based Photoaffinity Probe; 3-(4-(2-Quinazolin-4-yloxyethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine; 173219-33-5; Photoaffinity Labeling Reagent
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical reagent adheres to stringent quality protocols. Each batch is characterized and tested to ensure identity, purity, and performance consistency suitable for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), spectral data (NMR, MS), and functional performance is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize decomposition. The material is light-sensitive and easily oxidized; prolonged exposure to light, air, or elevated temperatures should be avoided. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.