Description

Nitine (Benzyl Analog of Taxol)(P) is a semi-synthetic taxane derivative, specifically a benzyl-substituted analog of the potent anticancer agent Paclitaxel. This compound is of significant interest in pharmaceutical research and development for its potential to offer modified biological activity and improved pharmacokinetic profiles. It serves as a critical intermediate and reference standard for researchers in oncology drug discovery, medicinal chemistry, and preclinical studies, aiming to develop novel chemotherapeutic agents with enhanced efficacy or reduced side effects.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel taxane-based anticancer drugs.
• Medicinal Chemistry Research: Used as a reference compound for structure-activity relationship (SAR) studies to optimize anticancer activity.
• Oncology Drug Discovery: Acts as a lead compound or analog for screening and developing new microtubule-stabilizing agents.
• Biochemical Research: Employed in studies investigating mechanisms of tubulin polymerization and apoptosis induction.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related substances.
• Preclinical Development: Supports in vitro and in vivo studies to evaluate pharmacokinetics, metabolism, and toxicity profiles.

Basic Information

Product Name	Nitine (Benzyl Analog of Taxol)(P)
CAS No.	173101-56-9
Molecular Formula	C47H51NO14
Molecular Weight	853.91 g/mol
Synonyms	Benzylpaclitaxel; 7-O-Benzylpaclitaxel; Taxol Benzyl Ether; 2a,4a,5b,7b,10b,13a-Hexahydro-4,7,10-trihydroxy-13-[(2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoyl]oxy-1,7,9-trioxo-5,20-epoxytax-11-en-9-one; 7-Benzyloxy Paclitaxel; Nitine; Paclitaxel 7-Benzyl Ether; Benzyl Analog of Taxol
EINECS	Contact for details

Quality Control

Our Nitine (Benzyl Analog of Taxol)(P) is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for analytical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert gas such as argon or nitrogen in a sealed container. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Maximum Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.