Description

Pmpa (NaaLadase Inhibitor) is a potent and selective inhibitor of the metalloenzyme N-acetylated-α-linked-acidic dipeptidase (NAALADase), also known as glutamate carboxypeptidase II. This compound is a critical research tool for studying glutamatergic neurotransmission and its role in neurological conditions. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and diagnostic developers focused on neuropathic pain, prostate cancer imaging, and neurodegenerative disease pathways.

Application

• Neuroscience Research: A key pharmacological tool for investigating the role of NAAG (N-acetylaspartylglutamate) and glutamate signaling in the central nervous system.
• Drug Discovery & Development: Used in high-throughput screening and target validation for therapies targeting neuropathic pain, schizophrenia, and addiction.
• Oncology Research: Serves as a reference compound in the development of PSMA (Prostate-Specific Membrane Antigen)-targeted imaging agents and therapeutics for prostate cancer.
• Biochemical Assay Development: Essential for standardizing and calibrating in vitro enzyme inhibition assays for NAALADase/PSMA activity.
• Academic & Institutional Labs: Fundamental reagent for graduate and post-doctoral research into glutamatergic pathways and metallopeptidase function.

Basic Information

Product Name	Pmpa (NaaLadase Inhibitor)
CAS No.	173039-10-6
Molecular Formula	C7H14N2O5P
Molecular Weight	237.17 g/mol
Synonyms	2-(Phosphonomethyl)pentanedioic acid; (R)-2-(Phosphonomethyl)pentanedioic acid; NAALADase Inhibitor; GPI-5693; PSMA Inhibitor; 2-PMPA; Glutamate Carboxypeptidase II Inhibitor; (R)-2-(Phosphonomethyl)glutaric acid
EINECS	Contact for details

Quality Control

Every batch of Pmpa (NaaLadase Inhibitor) is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including HPLC purity reports, identity confirmation (IR, NMR), and chiral purity analysis to ensure research-grade consistency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Biological Activity (IC50)	Reported per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.