Description

Varespladib CAS NO 172732-68-2 is a potent and selective secretory phospholipase A2 (sPLA2) inhibitor. This compound is of significant interest in pharmaceutical research and development, particularly for its potential therapeutic applications. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the discovery of novel anti-inflammatory and anti-venom agents.

Application

• Pharmaceutical Research: A key investigational agent for studying inflammatory pathways mediated by sPLA2 enzymes.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for conditions like sepsis, acute lung injury, and pancreatitis.
• Anti-Venom Research: Investigated for its potential to neutralize the effects of snake venom phospholipases A2, offering a novel therapeutic approach for envenomation.
• Biochemical Assays: Used as a specific inhibitor in enzymatic assays to study sPLA2 activity and function in various biological systems.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	Varespladib
CAS No.	172732-68-2
Molecular Formula	C31H34N2O5S
Molecular Weight	546.68 g/mol
Synonyms	LY315920; Varespladib sodium; (S)-3-(2-(4-(2-Amino-2-oxoacetyl)piperazin-1-yl)-2-oxoethyl)-2-(3-(4-(but-2-yn-1-yloxy)phenyl)propanamido)propanoic acid; A-001; sPLA2 Inhibitor
EINECS	Contact for details

Quality Control

Our Varespladib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.