Description

α-Ketoisocaproic-D3 Acid Sodium Salt is a high-purity, isotopically labeled derivative of α-ketoisocaproic acid, a key intermediate in leucine metabolism. This deuterated compound is essential for advanced research and development, providing a stable, non-radioactive tracer for precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic researchers in the life sciences sector.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as a critical internal standard for the accurate quantification of endogenous α-ketoisocaproic acid and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate the detailed catabolic and anabolic pathways of branched-chain amino acids, particularly leucine.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the development and validation of bioanalytical methods for novel therapeutics targeting metabolic disorders.
• Clinical Diagnostics Research: Facilitates the development of highly specific assays for diagnosing inborn errors of metabolism, such as maple syrup urine disease (MSUD).
• Biochemical Research: Acts as a substrate or reference compound in enzymatic studies involving branched-chain α-keto acid dehydrogenase complex (BCKDC) activity.
• Nutritional Science Studies: Used to investigate protein turnover, muscle metabolism, and the metabolic effects of dietary leucine.

Basic Information

Product Name	α-Ketoisocaproic-D3 Acid Sodium Salt
CAS No.	172330-01-7
Molecular Formula	C6H4D3NaO3
Molecular Weight	153.12 g/mol (approx.)
Synonyms	4-Methyl-2-oxopentanoic-3,4,5-D3 acid sodium salt; Sodium 2-oxo-4-methylpentanoate-3,4,5-D3; α-Keto-D3-isocaproate sodium salt; 2-Oxoisocaproic-D3 acid sodium salt; KIC-D3 sodium salt; Sodium α-ketoisocaproate-D3; (3,4,5-D3)-4-Methyl-2-oxopentanoic acid sodium salt
EINECS	Contact for details

Quality Control

Our α-Ketoisocaproic-D3 Acid Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm isotopic enrichment, chemical purity, and identity, ensuring consistency for critical research applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.