Description

Ras/Rac Transformation Blocker, Sch 51344 is a potent and selective small molecule inhibitor of the Ras/Rac signaling pathway. This compound is critical for researchers and developers investigating cellular transformation, oncogenesis, and metastasis, as it specifically blocks the downstream signaling events mediated by these key GTPases. It is an essential tool for pharmaceutical R&D, academic research in cancer biology, and the development of novel therapeutic strategies targeting Ras-driven cancers.

Application

• Cancer Research & Drug Discovery: A key pharmacological tool for studying Ras and Rac-mediated signal transduction pathways in oncogenesis and tumor progression.
• Cell Biology Studies: Used to investigate the role of Ras/Rac in cellular processes such as proliferation, differentiation, cytoskeletal reorganization, and cell migration.
• Target Validation: Employed in preclinical research to validate the Ras/Rac pathway as a therapeutic target for various cancers, including pancreatic, lung, and colorectal.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in screening assays designed to identify novel inhibitors of this pathway.
• Biochemical Assay Development: Utilized in developing and optimizing in vitro enzymatic or binding assays for Ras/Rac and their effector proteins.

Basic Information

Product Name	Ras/Rac Transformation Blocker, Sch 51344
CAS No.	171927-40-5
Molecular Formula	C₁₈H₁₈N₄O₃
Molecular Weight	338.36 g/mol
Synonyms	SCH-51344; SCH 51344; 2-[(8-Hydroxy-2-methyl-4-oxo-4H-chromen-7-yl)oxy]-N-(1H-pyrazol-3-yl)acetamide; Ras/Rac Inhibitor; Rac/Ras signaling inhibitor; Rac1 inhibitor SCH51344; 7-({2-[(1H-Pyrazol-3-yl)amino]-2-oxoethoxy}-8-hydroxy-2-methyl-4H-chromen-4-one
EINECS	Contact for details

Quality Control

Our Ras/Rac Transformation Blocker, Sch 51344 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.