Description

GGTI-286 is a potent, cell-permeable inhibitor of geranylgeranyl transferase I (GGTase I), a key enzyme in the post-translational modification of Rho family GTPases. It is widely employed in life science research to probe protein prenylation pathways and investigate oncogenic signaling mechanisms. Researchers in academic laboratories, biopharmaceutical R&D centers, and contract research organizations rely on GGTI-286 CAS NO 171744-11-9 for mechanistic studies in cancer biology, neurodegeneration, and inflammation.

Application

• Oncology research: Inhibition of Ras-related GTPase membrane localization and downstream tumor proliferation signaling
• Neuroscience studies: Modulation of RhoA/Rac1-dependent neurite outgrowth and synaptic plasticity
• Cardiovascular disease models: Investigation of geranylgeranylated protein roles in vascular smooth muscle cell migration
• Drug discovery screening: Primary and secondary assay tool compound for GGTase I target validation
• Combination therapy research: Synergy evaluation with farnesyl transferase inhibitors (FTIs) or kinase inhibitors
• Cell-based functional assays: Dose-response profiling in human cancer cell lines (e.g., HCT-116, A549, MDA-MB-231)
• Biomarker development: Correlation of GGTase I inhibition with prenylation status of substrates like Rap1A and RhoA

Basic Information

Product Name	GGTI-286
CAS No.	171744-11-9
Molecular Formula	C28H33ClN4O3S
Molecular Weight	541.11 g/mol
Synonyms	(2R)-2-[(2S,3S)-3-[(2-Amino-3-methylbutanoyl)amino]-2-hydroxy-4-methylpentanoyl]amino-3-(4-chlorophenyl)propanoic acid; GGTI-286 hydrate; GGTI286; N-[(2S,3S)-1-[(2R)-2-Amino-3-(4-chlorophenyl)propanoyl]pyrrolidin-2-yl]-3-methyl-2-[(methylsulfonyl)oxy]butanamide; L-778,123 analog; Geranylgeranyltransferase I inhibitor 286; (2R)-2-[(2S,3S)-3-[(2-Amino-3-methylbutanoyl)amino]-2-hydroxy-4-methylpentanoyl]amino-3-(4-chlorophenyl)propanoic acid; GGTase I inhibitor GGTI-286
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of GGTI-286 is verified for identity (HPLC retention time, IR spectroscopy), purity (≥98.5% by HPLC), residual solvents (ICH Class 3), heavy metals (<10 ppm), and water content (Karl Fischer). Testing conforms to ACS Reagent Grade and ISO 9001:2015 quality management requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) due to hygroscopic nature. Keep desiccated and avoid repeated exposure to ambient humidity. Handle in a controlled environment with low relative humidity (<30% RH) during weighing or dispensing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤1.5%
Water (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.