Description

Nortadalafil CAS NO 171596-36-4 is a high-purity pharmaceutical intermediate and research chemical. It is a key structural analog and precursor in the synthesis of advanced active pharmaceutical ingredients (APIs) within the PDE-5 inhibitor class. This compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical suppliers focused on cardiovascular and urological therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of tadalafil and related PDE-5 inhibitor APIs.
• Research & Development: Serves as a reference standard and starting material for medicinal chemistry research and novel drug discovery programs.
• Analytical Standard: Used in quality control laboratories for method development, validation, and impurity profiling via HPLC, LC-MS, and NMR.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized chemical entities.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and biochemical pathway analysis.

Basic Information

Product Name	Nortadalafil
CAS No.	171596-36-4
Molecular Formula	C₂₁H₁₉N₃O₄
Molecular Weight	377.40 g/mol
Synonyms	N-Desmethyl Tadalafil; (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; Tadalafil Impurity; Tadalafil Metabolite; Tadalafil Related Compound; PDE5 Inhibitor Intermediate; GR 34000 Impurity
EINECS	Contact for details

Quality Control

Our Nortadalafil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.