Description

cis-Tadalafil CAS NO 171596-27-3 is a specific stereoisomer of the well-known pharmaceutical compound tadalafil. This high-purity intermediate is critical for research and development in the pharmaceutical sector, particularly for investigating structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on advanced drug discovery and process chemistry.

Application

• Pharmaceutical Research & Development (R&D): A key intermediate for the synthesis and study of tadalafil analogs and derivatives to explore new therapeutic pathways.
• Process Chemistry Development: Used in the optimization and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) within controlled manufacturing environments.
• Analytical Reference Standard: Serves as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical analysis.
• Academic & Clinical Research: Employed in biochemical and pharmacological studies to understand the specific activity profile of the cis-isomer.
• Fine Chemical Synthesis: A building block for the custom synthesis of complex organic molecules and specialized chemical entities.

Basic Information

Product Name	cis-Tadalafil
CAS No.	171596-27-3
Molecular Formula	C₂₂H₁₉N₃O₄
Molecular Weight	389.41 g/mol
Synonyms	(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; cis-(6R,12aR)-Tadalafil; (6R,12aR)-Tadalafil; Tadalafil cis-isomer; Tadalafil Impurity; PDE5 Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our cis-Tadalafil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for isomeric content, and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide Certificates of Analysis (COA) with detailed batch-specific results to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.