Description

Exatecan is a potent, water-soluble camptothecin analog and a key pharmaceutical intermediate in the synthesis of advanced oncology therapeutics. Its primary value lies in its role as a topoisomerase I inhibitor, forming the active core of novel drug conjugates designed for targeted cancer therapy. This high-purity compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of next-generation chemotherapeutic agents, particularly antibody-drug conjugates (ADCs) and liposomal formulations targeting solid tumors.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel camptothecin-derived anticancer drugs.
• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead in ADC platforms, enabling targeted delivery to cancer cells.
• Oncology Research: Used in biochemical and pharmacological studies to investigate topoisomerase I inhibition mechanisms and cytotoxicity.
• Liposomal Drug Formulation: Incorporated into nanoparticle and liposomal delivery systems to improve therapeutic index and reduce systemic toxicity.
• Preclinical & Clinical Development: Supplied as a reference standard and active pharmaceutical ingredient (API) for drug development pipelines.
• Combinatorial Chemistry: Utilized in medicinal chemistry for the design and synthesis of new analogs with optimized efficacy and safety profiles.

Basic Information

Product Name	Exatecan
CAS No.	171335-80-1
Molecular Formula	C₂₄H₂₇N₃O₇
Molecular Weight	469.49 g/mol
Synonyms	DX-8951; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione; Exatecan mesylate (salt form); DX 8951; DX8951; (19S)-10,11-Difluoro-19-hydroxy-3-[(2-hydroxyethyl)amino]-19,20-dihydrocamptothecin
EINECS	Contact for details

Quality Control

Our Exatecan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical intermediate and API supply. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.