Description

Eglu CAS NO 170984-72-2 is a specialized chemical compound widely recognized as a potent and selective inhibitor of the enzyme glutamate carboxypeptidase II (GCPII), also known as NAALADase. This compound is crucial for advanced neuroscience research and pharmaceutical development, enabling precise modulation of glutamatergic signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurological disorders, prostate cancer research, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Used as a key pharmacological tool to study the role of NAAG (N-acetylaspartylglutamate) and glutamate in synaptic transmission, neurotoxicity, and models of neurological conditions.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel GCPII inhibitors for treating conditions like neuropathic pain, glioblastoma, and schizophrenia.
• Oncology Research: Investigated for its potential in prostate cancer imaging and therapy, leveraging the overexpression of PSMA (a homolog of GCPII) in prostate cancer cells.
• Biochemical Assays: Employed in in vitro enzymatic assays to measure GCPII activity and screen for inhibitory compounds.
• Academic & Preclinical Studies: Essential for university labs and CROs (Contract Research Organizations) conducting fundamental research on glutamate metabolism and its pathological implications.

Basic Information

Product Name	Eglu
CAS No.	170984-72-2
Molecular Formula	C15H18N2O5
Molecular Weight	306.32 g/mol
Synonyms	2-[[(2S)-2-[[(2S)-1-Hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]pentanedioic acid; (2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]succinyl-L-glutamic acid; GPI-5693; 2-PMPA; NAALADase Inhibitor; Glutamate Carboxypeptidase II Inhibitor; PSMA Inhibitor
EINECS	Contact for details

Quality Control

Our Eglu is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via NMR and Mass Spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Biological Activity (IC50)	Reported (nM range)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.