Description

Hanatoxin-2 CAS NO 170780-01-5 is a potent, selective peptide neurotoxin originally isolated from the venom of the Chilean rose tarantula (*Grammostola rosea*). This compound is a valuable research-grade biochemical tool for the study of voltage-gated potassium (Kv) channels, specifically Kv2.1 and Kv4 subfamilies. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, ion channel pharmacology, and drug discovery programs.

Application

• Neuroscience Research: As a specific blocker of Kv2.1 channels, it is used to study channel function, neuronal excitability, and action potential dynamics.
• Ion Channel Pharmacology: Serves as a critical reference standard and probe in high-throughput screening (HTS) assays to identify novel modulators of potassium channels.
• Drug Discovery & Development: Used in target validation and mechanistic studies for conditions related to potassium channel dysfunction, such as certain cardiac arrhythmias, epilepsy, and neurodegenerative diseases.
• Biochemical Tool Manufacturing: Incorporated into assay kits and research reagents sold to the life science research market.
• Academic & Clinical Research: Facilitates fundamental research into synaptic transmission, cellular signaling pathways, and the pathophysiology of channelopathies.

Basic Information

Product Name	Hanatoxin-2
CAS No.	170780-01-5
Molecular Formula	C185H273N51O49S6
Molecular Weight	~4290.8 g/mol
Synonyms	Hanatoxin 2; HaTx2; ω-Grammotoxin SIA; Voltage-gated potassium channel toxin HaTx2; Grammostola rosea Hanatoxin-2; ShK-like toxin 2; Kv2.1 channel blocker
EINECS	Contact for details

Quality Control

Our Hanatoxin-2 is produced and analyzed under strict quality protocols to ensure batch-to-batch consistency and research reliability. Each lot is characterized using advanced analytical techniques including HPLC for purity and mass spectrometry for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and biological activity, supporting compliance with rigorous research standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50, Kv2.1)	≤ 50 nM (Reported with COA)
Solubility	Soluble in aqueous buffers or DMSO
Endotoxin Level	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.