Description

Sb 216641 Hydrochloride is a potent and selective small molecule inhibitor of the protein kinase GSK-3β (Glycogen Synthase Kinase-3 beta). This compound matters significantly for researchers investigating signaling pathways related to cell proliferation, metabolism, and neurological function. It is primarily needed by pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on oncology, neurodegenerative diseases, and metabolic disorders. The high-purity material is essential for generating reliable and reproducible data in biochemical and cellular assays.

Application

• Biochemical Research: Used as a selective tool compound to inhibit GSK-3β activity in in vitro kinase assays to study substrate phosphorylation and pathway modulation.
• Cell-Based Studies: Applied in cellular models to investigate the role of GSK-3β in Wnt/β-catenin signaling, apoptosis, and insulin signaling pathways.
• Neuroscience Research: Employed in studies exploring GSK-3β's involvement in tau phosphorylation, synaptic plasticity, and potential links to Alzheimer's disease and other tauopathies.
• Oncology Research: Utilized to probe the effects of GSK-3β inhibition on cancer cell proliferation, survival, and chemoresistance in various tumor models.
• Metabolic Disorder Research: A key reagent for studying the kinase's role in glycogen synthesis and glucose metabolism, relevant to type 2 diabetes.
• Drug Discovery & Development: Serves as a pharmacological reference standard and a starting point for structure-activity relationship (SAR) studies in medicinal chemistry programs targeting GSK-3.

Basic Information

Item	Details
Product Name	Sb 216641 Hydrochloride
CAS No.	170230-44-1
Molecular Formula	C₁₆H₁₂ClN₃O₃S • HCl
Molecular Weight	398.27 g/mol
Synonyms	SB-216641 hydrochloride; 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; GSK-3β Inhibitor IX; GSK-3 Inhibitor IX; SB216641; SB 216641; CTK4G0775; BDBM50111657; 1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our Sb 216641 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and identity verification by NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass Spec)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.