Description

Sb 216641 Hydrochloride is a potent and selective inhibitor of the p38α MAP kinase, a key signaling protein involved in cellular stress and inflammatory responses. This compound is a critical research tool for investigating the role of p38 MAPK pathways in disease models, particularly inflammation, neurodegeneration, and cancer. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and molecular biology studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the p38 MAPK signaling cascade and its downstream effects in cell-based assays.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool for validating targets and screening novel anti-inflammatory or neuroprotective agents.
• Academic Research: Employed in university and institutional labs to explore mechanisms of inflammation, apoptosis, and cytokine production.
• In Vitro Diagnostics: May be used in the development of diagnostic assays to measure p38 MAPK activity in pathological samples.
• Preclinical Studies: Applied in animal models to investigate the therapeutic potential of p38 inhibition for conditions like rheumatoid arthritis, Crohn's disease, or Alzheimer's disease.

Basic Information

Product Name	Sb 216641 Hydrochloride
CAS No.	170230-39-4
Molecular Formula	C₁₈H₁₉Cl₂N₃O₂
Molecular Weight	380.27 g/mol
Synonyms	SB-216641 hydrochloride; 1-[3-(Trifluoromethyl)phenyl]piperazine hydrochloride; SB216641; p38 MAP Kinase Inhibitor SB 216641; 1-(3-(Trifluoromethyl)phenyl)piperazine HCl; SB-216641 HCl; N-(3-Trifluoromethylphenyl)piperazine hydrochloride
EINECS	Contact for details

Quality Control

Our Sb 216641 Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet the stringent requirements of GLP (Good Laboratory Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.