Description

Fti-277 is a potent and selective inhibitor of farnesyltransferase, a key enzyme in the post-translational modification of signaling proteins like Ras. This compound is a critical research tool for investigating oncogenic pathways and cellular proliferation mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cancer biology, signal transduction studies, and drug discovery programs. Fti-277 CAS NO 170006-73-2 represents a high-purity biochemical reagent essential for advancing therapeutic research.

Application

• Biochemical Research: Used as a selective farnesyltransferase inhibitor to study Ras protein signaling pathways and their role in cell growth and differentiation.
• Cancer Research: A vital tool in oncology research for investigating the inhibition of Ras-dependent tumorigenesis and evaluating potential anti-cancer therapeutics.
• Signal Transduction Studies: Employed to dissect the farnesylation-dependent activation mechanisms of various proteins involved in intracellular signaling cascades.
• Drug Discovery & Development: Serves as a reference compound and a lead molecule in high-throughput screening and the development of novel farnesyltransferase inhibitors.
• Academic & Pharmaceutical R&D: Essential for laboratory experiments in universities, research institutes, and pharmaceutical R&D departments focusing on molecular biology and pharmacology.

Basic Information

Product Name	Fti-277
CAS No.	170006-73-2
Molecular Formula	C27H30N4O4S
Molecular Weight	506.62 g/mol
Synonyms	Farnesyltransferase Inhibitor III; (S)-2-[2-[(2R,5S)-5-[[(2S)-3-Mercapto-2-methyl-1-oxopropyl]amino]-2-oxo-1-piperidinyl]-4-(methylthio)-1-oxobutyl]amino]-4-(methylthio)butanoic Acid 1,1-Dimethylethyl Ester; FTI-277; FTI 277; Fti277; L-744,832 analog.
EINECS	Contact for details

Quality Control

Our Fti-277 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.