Description

Fti-276 is a potent and selective inhibitor of farnesyltransferase, a key enzyme in the post-translational modification of Ras and other proteins. This compound is a critical research tool for investigating the role of protein farnesylation in cellular signaling, proliferation, and oncogenesis. It is primarily utilized by researchers and pharmaceutical developers in the fields of oncology, cell biology, and drug discovery. The product is supplied as Fti-276 CAS NO 170006-72-1.

Application

• Biomedical Research: A fundamental tool for studying Ras-mediated signal transduction pathways and the biological consequences of inhibiting protein farnesylation.
• Oncology Studies: Used in vitro and in vivo to investigate the therapeutic potential of farnesyltransferase inhibition for various cancers, including pancreatic, colon, and lung carcinomas.
• Drug Discovery & Development: Serves as a reference compound and a lead structure for the design and screening of novel anti-cancer therapeutics targeting the Ras pathway.
• Cell Biology: Employed to elucidate the role of prenylated proteins in cell cycle regulation, cytoskeletal organization, and apoptosis.
• Mechanism of Action Studies: Essential for validating farnesyltransferase as a drug target and understanding resistance mechanisms in cancer cells.

Basic Information

Product Name	Fti-276
CAS No.	170006-72-1
Molecular Formula	C27H30N4O4
Molecular Weight	474.56 g/mol
Synonyms	Farnesyltransferase Inhibitor I; FTI-276; (S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-4-(methylsulfonyl)butanoic Acid; (αS,2S,3S)-α-[[(1S)-1-[[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methyl-1-oxopentyl]amino]-N-(3-phenyl-1-oxopropyl)methanesulfonylalaninamide; B581
EINECS	Contact for details

Quality Control

Our Fti-276 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR/LC-MS for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for your records and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.