Description

Ruboxistaurin Mesylate is a selective inhibitor of protein kinase C beta (PKC-β), a compound of significant interest in pharmaceutical research and development. Its primary value lies in its potential therapeutic applications for complications arising from diabetes, particularly diabetic microvascular complications. This makes it a critical material for pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) focused on metabolic disease and ophthalmic drug discovery. The compound is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate for advanced research and formulation studies.

Application

• Primary reference standard for analytical method development and validation in pharmaceutical quality control laboratories.
• Key intermediate in the research-scale synthesis of Ruboxistaurin Mesylate active pharmaceutical ingredient (API).
• Pharmacological research tool for studying the role of protein kinase C beta (PKC-β) in diabetic complications, including retinopathy and neuropathy.
• Pre-clinical and clinical research material for investigating therapeutic interventions for diabetic macular edema.
• Building block for medicinal chemistry programs aimed at developing novel PKC-β inhibitors.
• Component in formulation studies for ophthalmic or oral dosage forms during drug development stages.

Basic Information

Product Name	Ruboxistaurin Mesylate
CAS No.	169939-94-0
Molecular Formula	C₂₉H₂₈N₄O₃ • CH₄O₃S
Molecular Weight	552.64 g/mol
Synonyms	Ruboxistaurin Mesylate; Ruboxistaurin Methanesulfonate; LY333531 Mesylate; (S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione methanesulfonate; Arxxant (proposed trade name); PKC-β Inhibitor LY333531 Mesylate
EINECS	Contact for details

Quality Control

Our Ruboxistaurin Mesylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.