Description

Ruboxistaurin Hydrochloride is a selective inhibitor of protein kinase C beta (PKC-β), a compound of significant interest in pharmaceutical research and development. Its primary value lies in its potential to modulate biochemical pathways implicated in diabetic microvascular complications, particularly diabetic retinopathy and neuropathy. This makes it a critical material for researchers in the life sciences sector, pharmaceutical companies engaged in drug discovery, and contract research organizations (CROs) focused on metabolic and vascular diseases.

Application

• Pharmaceutical R&D: Key intermediate or active pharmaceutical ingredient (API) in the development of therapeutics for diabetic complications.
• Biochemical Research: Used as a potent and selective tool compound in vitro and in vivo to study PKC-β signaling pathways and their role in disease pathology.
• Preclinical Studies: Essential for efficacy and safety testing in animal models of diabetes, retinopathy, and neuropathy.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Mechanism of Action Studies: Facilitates research into the molecular mechanisms underlying vascular endothelial dysfunction.

Basic Information

Product Name	Ruboxistaurin Hydrochloride
CAS No.	169939-93-9
Molecular Formula	C₂₇H₂₆N₄O₄ • HCl
Molecular Weight	502.98 g/mol
Synonyms	LY333531 Hydrochloride; (S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione Hydrochloride; Ruboxistaurin HCl; PKC-β Inhibitor
EINECS	Contact for details

Quality Control

Our Ruboxistaurin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-grade research standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.