Description

Ruboxistaurin is a potent and selective inhibitor of protein kinase C beta (PKC-β), a key enzyme implicated in the pathogenesis of diabetic microvascular complications. This compound is of significant interest for research and development within the pharmaceutical and life sciences sectors. It is primarily utilized by researchers and manufacturers focused on metabolic disorders, diabetic complications, and advanced ophthalmic therapeutics.

Application

• Pharmaceutical Research & Development: A critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics for diabetic retinopathy, neuropathy, and nephropathy.
• Biochemical Research: Used as a selective pharmacological tool to study PKC-β signaling pathways, cellular mechanisms, and their role in vascular dysfunction and oxidative stress.
• Preclinical Studies: Employed in animal models to investigate the efficacy and pharmacokinetics of PKC-β inhibition for treating microvascular complications associated with diabetes.
• Analytical Standard: Serves as a high-purity standard for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.
• Academic Research: Utilized in university and institutional labs for fundamental research into kinase biology and drug discovery projects.

Basic Information

Product Name	Ruboxistaurin
CAS No.	169939-91-7
Molecular Formula	C₂₇H₂₅N₃O₄
Molecular Weight	455.51 g/mol
Synonyms	LY333531; (S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione; Arxxant; Protein Kinase C Beta Inhibitor LY333531; Ruboxistaurin Mesylate (salt form precursor)
EINECS	Contact for details

Quality Control

Our Ruboxistaurin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets high-grade research standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.