Description

Tyrphostin Ag 1433 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for studying signal transduction pathways involved in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by researchers and pharmaceutical developers in the fields of biochemical research, cancer biology, and drug discovery.

Application

• Biochemical Research: A key reagent for investigating EGFR-mediated signaling cascades and their role in cellular processes.
• Cancer Biology Studies: Used to inhibit EGFR activity in vitro and in vivo to study tumor growth, metastasis, and potential therapeutic targets.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the screening and development of novel tyrosine kinase inhibitors.
• Cellular Pathway Analysis: Employed to dissect the specific contributions of EGFR to complex cellular responses and phenotypes.
• Academic & Institutional Research: Fundamental tool for universities and research institutes conducting basic science in molecular biology and pharmacology.

Basic Information

Product Name	Tyrphostin Ag 1433
CAS No.	168836-03-1
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 1433; AG-1433; Tyrphostin AG 1433; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline; NSC 710295; EGFR Tyrosine Kinase Inhibitor AG1433; EGFR Inhibitor AG1433
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 1433 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure high consistency and reliability for research applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.