Description

Tyrphostin Ag1433 is a potent and selective small-molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for investigating signal transduction pathways involved in cell proliferation, differentiation, and survival. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for drug discovery, target validation, and fundamental biochemical studies.

Application

• Biochemical Research: A key reagent for studying EGFR-mediated signaling cascades and their role in cellular processes.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in screening assays and target validation for oncology research.
• Cancer Research: Investigated for its effects on tumor cell growth and proliferation in various in vitro and ex vivo models.
• Signal Transduction Studies: Employed to dissect and inhibit specific tyrosine kinase pathways to understand disease mechanisms.
• Academic & Institutional Research: Supports fundamental scientific investigations in molecular biology and cell signaling.

Basic Information

Product Name	Tyrphostin Ag1433
CAS No.	168835-90-3
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 1433; AG-1433; Tyrphostin AG 1433; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline; 6,7-Dimethoxy-4-[(3-bromophenyl)amino]quinazoline; EGFR Tyrosine Kinase Inhibitor AG1433; ZD 1839 Analog
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag1433 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Each lot is supplied with a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.