Description

Combretastatin A4 Phosphate Disodium Salt is a potent water-soluble prodrug of the natural microtubule destabilizing agent Combretastatin A4, designed for enhanced bioavailability and targeted delivery. This compound is a critical research tool and a key intermediate in the development of vascular disrupting agents (VDAs) for oncology applications. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on anticancer drug discovery and preclinical studies.

Application

• Anticancer Research: A vital reference standard and active pharmaceutical ingredient (API) in the study of vascular disrupting agents and tubulin polymerization inhibitors.
• Preclinical Drug Development: Used in in vitro and in vivo models to evaluate efficacy against various solid tumor types.
• Mechanistic Studies: Employed to investigate the biological pathways of tumor vasculature shutdown and apoptosis induction.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of more complex therapeutic conjugates or formulations.
• Biochemical Assays: Used as a control compound in high-throughput screening (HTS) campaigns targeting the cytoskeleton.

Basic Information

Product Name	Combretastatin A4 Phosphate Disodium Salt
CAS No.	168555-66-6
Molecular Formula	C18H19N2Na2O9P
Molecular Weight	492.29 g/mol
Synonyms	CA4P; Combretastatin A-4 Phosphate Disodium; Fosbretabulin Disodium; (Z)-2-Methoxy-5-[(3,4,5-trimethoxyphenyl)methylidene]phenyl Dihydrogen Phosphate Disodium Salt; ZD-6126; AC-7700; Disodium (Z)-2-methoxy-5-[(3,4,5-trimethoxyphenyl)methylene]phenyl phosphate; Combretastatin A4 Prodrug
EINECS	Contact for details

Quality Control

Our Combretastatin A4 Phosphate Disodium Salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.