Description

7-Hydroxy Coumarin 2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is a high-purity, synthetically derived glucuronide conjugate of 7-hydroxycoumarin, serving as a critical reference standard and synthetic intermediate. This compound is essential for analytical method development and validation in pharmacokinetic and metabolic studies, providing a stable, acetyl-protected form for precise quantification. It is primarily utilized by research institutions, pharmaceutical developers, and contract research organizations (CROs) focused on drug metabolism and ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.

Application

• Pharmaceutical Reference Standard: Certified material for the calibration and validation of HPLC, LC-MS, and other analytical methods in bioanalytical laboratories.
• Drug Metabolism Research: Key intermediate for studying the glucuronidation pathway, a major Phase II metabolism route for xenobiotics and drugs.
• Biomarker Development: Used in the synthesis and quantification of specific metabolite biomarkers for clinical and preclinical studies.
• Enzyme Activity Assays: Substrate or standard for investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Chemical Synthesis: Advanced synthetic building block for creating more complex fluorogenic or tagged probes for biological imaging.
• Quality Control: Serves as an impurity standard or system suitability compound in the quality control of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	7-Hydroxy Coumarin 2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester
CAS No.	168286-97-3
Molecular Formula	C₂₂H₂₄O₁₃
Molecular Weight	520.42 g/mol
Synonyms	7-Hydroxycoumarin glucuronide methyl ester triacetate; Hymecromone glucuronide methyl ester triacetate; 4-Methylumbelliferone glucuronide methyl ester triacetate; 7-Hydroxy-4-methylcoumarin 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronic acid methyl ester; β-D-Glucopyranosiduronic acid, 7-hydroxy-4-methyl-2H-1-benzopyran-2-one 2,3,4-triacetate, methyl ester; 4-MU-Glucuronide methyl ester triacetate; 7-HC-Gluc triacetate methyl ester
EINECS	Contact for details

Quality Control

Every batch of 7-Hydroxy Coumarin 2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure compliance with research and reference standard grade specifications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.