Description

Abl Cytosolic Substrate CAS NO 168202-46-8 is a specialized biochemical reagent designed as a selective substrate for Abl (Abelson) tyrosine kinase activity. This compound is critical for researchers studying intracellular signaling pathways, particularly those involved in cell growth, differentiation, and apoptosis. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic assay development in the fields of oncology and cellular biology.

Application

• Kinase Activity Assays: Primary substrate for in vitro enzymatic assays to measure Abl kinase inhibition or activation.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel tyrosine kinase inhibitors (TKIs) for cancer therapy.
• Biochemical Research: Fundamental tool for studying signal transduction mechanisms, phosphorylation events, and pathway regulation in cytosolic fractions.
• Diagnostic Development: Key component in developing clinical diagnostic tests for diseases associated with dysregulated Abl kinase activity.
• Academic & Institutional Research: Supports basic science investigations into cellular processes and disease models in university and government laboratories.

Basic Information

Product Name	Abl Cytosolic Substrate
CAS No.	168202-46-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Abl Substrate Peptide; c-Abl Substrate; Abl Kinase Substrate; Tyrosine Kinase Abl Substrate; p160 BCR Substrate; BCR-ABL Substrate Peptide; Cytosolic Abl Substrate; CAS 168202-46-8
EINECS	Contact for details

Quality Control

Our Abl Cytosolic Substrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and performance for critical research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reliable and reproducible results in your assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, buffered aqueous solutions
Biological Activity	Validated in standard kinase assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.