Description

Zosuquidar Trihydrochloride is a potent and selective third-generation P-glycoprotein (P-gp) inhibitor used in pharmaceutical research and development. Its core value proposition lies in its ability to modulate multidrug resistance (MDR), a major challenge in oncology, by blocking the efflux of chemotherapeutic agents from cancer cells. This compound is essential for researchers and pharmaceutical manufacturers focused on developing novel cancer therapies, drug delivery systems, and studying drug transport mechanisms. It is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate.

Application

• Oncology Research: Investigation of P-glycoprotein-mediated multidrug resistance (MDR) reversal in various cancer cell lines.
• Drug Delivery Enhancement: Used in preclinical studies to improve the bioavailability and efficacy of co-administered chemotherapeutic drugs.
• Pharmacokinetic Studies: A critical tool for studying the absorption, distribution, metabolism, and excretion (ADME) of P-gp substrate drugs.
• API Intermediate: Serves as a key synthetic intermediate in the production of finished pharmaceutical products targeting MDR.
• Biochemical Assays: Employed in in vitro assays to characterize P-gp function and inhibitor potency.
• Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	Zosuquidar Trihydrochloride
CAS No.	167465-36-3
Molecular Formula	C32H31F2N3O2 • 3HCl
Molecular Weight	632.98 g/mol (as free base: 527.61 g/mol)
Synonyms	LY335979; Zosuquidar 3HCl; (R)-Valspodar; LY-335979; NSC-770176; 3-[[(2S)-6,7-Dimethoxy-2-[[2-(3,4,5-trimethoxyphenyl)ethyl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]methyl]-5-fluoro-1H-indole trihydrochloride
EINECS	Contact for details

Quality Control

Our Zosuquidar Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, residual solvent analysis, and identity confirmation (IR, NMR, MS). A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.