Description

5-Amino-2-Chloro-4-Nitrobenzotrifluoride is a high-value, multi-functional aromatic intermediate featuring amino, chloro, nitro, and trifluoromethyl substituents. This unique combination of functional groups makes it a versatile building block for synthesizing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty dyes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology treatments.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Dye and Pigment Manufacturing: Serves as a building block for synthesizing high-performance, light-fast azo dyes and organic pigments.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and electronic materials due to its electron-withdrawing properties.
• Cross-Coupling Reactions: The chloro and amino groups make it a suitable substrate for palladium-catalyzed reactions like Buchwald-Hartwig amination and Suzuki couplings.
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	5-Amino-2-Chloro-4-Nitrobenzotrifluoride
CAS No.	167415-22-7
Molecular Formula	C7H4ClF3N2O2
Molecular Weight	240.57 g/mol
Synonyms	2-Chloro-5-amino-4-nitrobenzotrifluoride; 2-Chloro-4-nitro-5-aminobenzotrifluoride; 5-Amino-2-chloro-4-nitro-α,α,α-trifluorotoluene; 2-Chloro-α,α,α-trifluoro-5-amino-4-nitrotoluene; 2-Chloro-4-nitro-5-(trifluoromethyl)aniline; 2-Chloro-5-nitro-4-(trifluoromethyl)aniline; Benzenamine, 2-chloro-4-nitro-5-(trifluoromethyl)-; 5-Amino-2-chloro-4-nitrobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Chloro-4-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of our global clientele. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.