Description

Zosuquidar is a potent and selective third-generation P-glycoprotein (P-gp) inhibitor, widely recognized for its role in overcoming multidrug resistance (MDR) in cancer therapy. Its primary value lies in its ability to block the efflux pump mechanism, thereby enhancing the intracellular concentration and efficacy of co-administered chemotherapeutic agents. This compound is essential for pharmaceutical R&D, particularly in oncology research, and for manufacturers developing novel therapeutic formulations and combination treatments.

Application

• Oncology Research: Critical for in vitro and in vivo studies aimed at reversing P-gp-mediated multidrug resistance in various cancer cell lines.
• Drug Development: Used as a pharmacological tool and reference standard in the development of new chemosensitizers and combination therapies.
• Pharmacokinetic Studies: Employed to investigate drug-drug interactions and the role of efflux transporters at biological barriers like the blood-brain barrier.
• Biochemical Assays: Serves as a specific inhibitor in functional assays to characterize P-gp activity and screen for new MDR modulators.
• Academic & Clinical Research: Fundamental for mechanistic studies exploring the pathways of drug resistance and potential therapeutic interventions.

Basic Information

Product Name	Zosuquidar
CAS No.	167354-40-7
Molecular Formula	C32H31F2N3O2
Molecular Weight	527.61 g/mol
Synonyms	LY335979; Zosuquidar trihydrochloride; LY-335979; (R)-4-((1aR,6R,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cyclohepten-6-yl)-α-((5-quinolyloxy)methyl)-1-piperazineethanol; 1-Piperazineethanol, 4-((1aR,6R,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cyclohepten-6-yl)-α-((5-quinolyloxy)methyl)-, (αR)-; P-glycoprotein inhibitor LY335979
EINECS	Contact for details

Quality Control

Our Zosuquidar is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet high-grade standards, specific pharmacopeial certifications (e.g., USP reference standard grade) are available upon request and customization.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.