Description

S-Didemethyl Citalopram is a key chiral intermediate and metabolite in the synthesis and study of the widely prescribed antidepressant, citalopram. This compound matters for its critical role in pharmaceutical research and development, enabling the study of metabolic pathways and the production of high-purity active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories focused on neuropharmacology and chiral chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of citalopram and its enantiomerically pure derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify drug metabolites in pharmacokinetic and pharmacodynamic research.
• Chiral Chemistry Research: Serves as a model compound in studies exploring stereoselective synthesis and separation techniques.
• Active Pharmaceutical Ingredient (API) Development: Employed in the research and process development for next-generation selective serotonin reuptake inhibitors (SSRIs).
• Quality Control & Impurity Profiling: Utilized as a certified reference material to identify and control related substances in citalopram drug substance and finished product manufacturing.

Basic Information

Product Name	S-Didemethyl Citalopram
CAS No.	166037-78-1
Molecular Formula	C18H19FN2O
Molecular Weight	298.36 g/mol
Synonyms	(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; (S)-Didemethylcitalopram; S-Didesmethylcitalopram; Lu AA21004; (3S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile; S-DDCIT; SCIT Metabolite
EINECS	Contact for details

Quality Control

Our S-Didemethyl Citalopram is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-Enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.