Description

Teriparatide Acetate is a synthetic polypeptide hormone and the acetate salt form of the active N-terminal fragment of human parathyroid hormone. This compound is a critical active pharmaceutical ingredient (API) with significant therapeutic value in the treatment of osteoporosis. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced bone metabolism therapies. Its precise biological activity makes it essential for formulating injectable medications that stimulate new bone formation.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the treatment of postmenopausal osteoporosis.
• Anabolic Bone Therapy: Key component in medications designed to increase bone mineral density and reduce fracture risk in patients with severe osteoporosis.
• Biomedical Research: Used as a reference standard and investigational tool in studies of bone physiology, calcium metabolism, and PTH receptor signaling pathways.
• Drug Development: Serves as a critical raw material for R&D departments formulating generic or novel drug delivery systems for parathyroid hormone analogs.
• Clinical Manufacturing: Employed in the cGMP-compliant production of batches for clinical trials involving bone growth stimulants.

Basic Information

Product Name	Teriparatide Acetate
CAS No.	165967-81-7
Molecular Formula	C₁₈₁H₂₉₁N₅₅O₅₁S₂ • xC₂H₄O₂
Molecular Weight	~4117.8 g/mol (free base)
Synonyms	Teriparatide acetate; Parathyroid Hormone (1-34), human, acetate; PTH (1-34) acetate salt; Recombinant human parathyroid hormone (1-34) acetate; Forteo™ API (acetate form); LY333334 acetate; hPTH(1-34) acetate
EINECS	Contact for details

Quality Control

Our Teriparatide Acetate is manufactured and tested under strict quality systems. We provide material that meets high-purity standards suitable for pharmaceutical development and manufacturing. A comprehensive Certificate of Analysis (COA) is supplied with each batch, detailing results for identity, purity, potency, and specific impurities. Our quality commitment aligns with ICH guidelines, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. For long-term storage, maintain at -70°C. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Store in a dedicated freezer away from volatile substances.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous, acetic acid-free basis)
Purity (Related Substances, HPLC)	Total related substances ≤ 5.0%
Single Unknown Impurity	≤ 2.0%
Potency (Bioassay)	90% - 115% of stated potency
Water Content (KF)	≤ 10.0%
Acetic Acid Content (HPLC)	1.0% - 10.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.