Description

4-(Pyrrolidine-1-Sulfonyl)-Benzenesulfonyl Chloride is a specialized bifunctional sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual reactive sites, enabling the efficient construction of complex sulfonamide and sulfonate structures with high selectivity. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly protease inhibitors and kinase inhibitors, where the sulfonamide moiety is a common pharmacophore.
• Agrochemical Synthesis: Used in creating new generations of herbicides, fungicides, and insecticides that require specific sulfonyl-based active ingredients.
• Polymer Modification: Acts as a cross-linking or functionalizing agent for engineering polymers, imparting specific chemical resistance or surface properties.
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) and affinity labels for studying enzyme function and target identification.
• Ligand Synthesis for Catalysis: Building block for creating sophisticated sulfonamide-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Dye and Pigment Manufacturing: Intermediate in the production of specialized sulfonated dyes and colorants with enhanced properties.

Basic Information

Product Name	4-(Pyrrolidine-1-Sulfonyl)-Benzenesulfonyl Chloride
CAS No.	165669-32-9
Molecular Formula	C11H12ClNO4S2
Molecular Weight	321.80 g/mol
Synonyms	4-(Pyrrolidine-1-sulfonyl)benzenesulfonyl chloride; 1-(4-(Chlorosulfonyl)phenylsulfonyl)pyrrolidine; 4-(1-Pyrrolidinylsulfonyl)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-(1-pyrrolidinylsulfonyl)-; 4-(Pyrrolidine-1-sulfonyl)phenylsulfonyl chloride; 165669-32-9; 4-(N-Pyrrolidinosulfonyl)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-(Pyrrolidine-1-Sulfonyl)-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.