Description

3-Acetyl-5-Chlorothiophene-2-Sulfonyl Chloride is a high-purity, multi-functional sulfonyl chloride derivative and a key advanced intermediate in organic synthesis. Its value lies in its dual reactive sites, making it an essential building block for constructing complex molecules with tailored properties. This compound is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting various enzyme families where the sulfonamide moiety is pharmacologically active.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for enhanced bioactivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialty polymers, coatings, and electronic materials with specific functional properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes to study biological pathways.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex heterocyclic dyes and organic pigments.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a sulfonyl chloride group onto a chlorinated thiophene core.

Basic Information

Product Name	3-Acetyl-5-Chlorothiophene-2-Sulfonyl Chloride
CAS No.	165117-07-7
Molecular Formula	C6H4Cl2O3S2
Molecular Weight	259.13 g/mol
Synonyms	5-Chloro-3-acetylthiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-chloro-3-acetyl-; 3-Acetyl-5-chloro-2-thiophenesulfonyl chloride; 5-Chloro-3-acetyl-2-thiophenesulfonyl chloride; 2-Thiophenesulfonyl chloride, 3-acetyl-5-chloro-; 3-Acetyl-5-chlorothiophene-2-sulfonylchloride; 165117-07-7
EINECS	Contact for details

Quality Control

Our 3-Acetyl-5-Chlorothiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.