Description

4-Keto 9-Cis Retinoic Acid Methyl Ester is a synthetic retinoid derivative, a methylated analog of 4-oxo-retinoic acid with a cis configuration at the 9-position. This specific stereochemistry and functional group modification make it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by R&D chemists and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for synthesizing novel retinoid-based therapeutics and conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel retinoid receptor agonists and antagonists.
• Biomedical Research: Used in studying retinoid signaling pathways, cellular differentiation, and apoptosis for potential cancer and dermatology treatments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Cosmeceutical R&D: Investigated for potential applications in advanced anti-aging and skin-rejuvenation formulations.
• Chemical Biology Probes: Utilized in the development of molecular probes to study vitamin A metabolism and related enzymatic processes.

Basic Information

Item	Details
Product Name	4-Keto 9-Cis Retinoic Acid Methyl Ester
CAS No.	163955-59-7
Molecular Formula	C21H28O3
Molecular Weight	328.45 g/mol
Synonyms	9-cis-4-Oxo-13-retinoic Acid Methyl Ester; Methyl 9-cis-4-oxoretinoate; 9Z-Retinoic Acid, 4-oxo-, Methyl Ester; 4-Oxo-9-cis-retinoic Acid Methyl Ester; 9-cis-4-Ketoretinoic Acid Methyl Ester; (2E,4E,6E,8E)-9-(2-Methoxy-2-oxoethyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic Acid Methyl Ester (IUPAC)
EINECS	Contact for details

Quality Control

Every batch of 4-Keto 9-Cis Retinoic Acid Methyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and MS. Our quality commitment ensures the material meets the high-purity standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.