Description

Sulfonyl Chloride, Polymer-Bound is a specialized functionalized resin designed for solid-phase synthesis and scavenging applications. This reagent offers significant advantages in purification workflows by enabling the covalent capture of target molecules or by-products, streamlining the isolation of high-purity compounds. It is an essential tool for researchers and process chemists in pharmaceutical development, combinatorial chemistry, and high-throughput screening who require efficient and reliable methods for compound library synthesis and purification.

Application

• Solid-Phase Organic Synthesis (SPOS): As a key building block for the immobilization of amines, alcohols, and other nucleophiles on solid support.
• Scavenging of Nucleophiles: Efficient removal of excess amines, hydrazines, or other basic impurities from reaction mixtures post-synthesis.
• Parallel and Combinatorial Chemistry: Facilitating the rapid generation of compound libraries through resin-bound intermediates.
• Peptide and Oligonucleotide Synthesis: Used in the preparation and modification of biomolecules on solid support.
• Catalyst and Reagent Recovery: Enabling the immobilization of catalysts or reagents for simplified recovery and reuse.
• High-Throughput Purification: Integration into automated purification systems for drug discovery pipelines.
• Derivatization for Analytical Chemistry: Preparation of samples for analysis by covalently binding analytes to a solid phase.

Basic Information

Product Name	Sulfonyl Chloride, Polymer-Bound
CAS No.	163894-16-4
Molecular Formula	Polymer-Bound (Typically polystyrene-based)
Molecular Weight	N/A (Polymer-supported reagent)
Synonyms	Polymer-bound sulfonyl chloride; Polystyrene-bound sulfonyl chloride; Sulfonyl chloride resin; Solid-supported sulfonyl chloride; SC resin; PS-SO2Cl; Merrifield resin sulfonyl chloride derivative; 4-(Chlorosulfonyl)polystyrene; Benzenesulfonyl chloride, polymer-bound
EINECS	Contact for details

Quality Control

Our Sulfonyl Chloride, Polymer-Bound is manufactured under controlled conditions to ensure consistent performance and high functional group loading. Each batch is characterized for key parameters including loading capacity, particle size distribution, and swelling properties. Certificates of Analysis (COA) detailing lot-specific data are available upon request, providing transparency and traceability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain reactivity and prevent degradation. Keep away from strong bases and nucleophiles.

Specification

Item	Specification
Appearance	Off-white to beige beads
Loading Capacity	0.5 - 2.0 mmol/g (Typical)
Matrix	Polystyrene cross-linked with divinylbenzene (1-2%)
Particle Size	100-200 mesh (or as specified)
Moisture Content (Karl Fischer)	< 1.0 %
Functional Group Integrity (IR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.