Description

Auristatin F is a highly potent synthetic derivative of dolastatin 10, a natural marine cytotoxin. This compound serves as a critical payload in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is essential for pharmaceutical R&D and bioconjugation specialists focused on creating next-generation oncology treatments. The product is supplied as a high-purity reference standard and building block for advanced therapeutic applications.

Application

• Primary payload for constructing novel Antibody-Drug Conjugates (ADCs) targeting various cancers.
• Key intermediate in the research and development of targeted chemotherapeutic agents.
• Critical reference standard for analytical method development and quality control in ADC manufacturing.
• Tool compound for studying mechanisms of action involving tubulin inhibition and apoptosis induction.
• Building block for the synthesis of modified cytotoxin analogs with tailored potency and linker compatibility.
• Used in preclinical studies to evaluate the efficacy and safety profiles of new conjugate therapies.

Basic Information

Product Name	Auristatin F
CAS No.	163768-50-1
Molecular Formula	C₄₅H₇₀N₆O₁₀
Molecular Weight	855.1 g/mol
Synonyms	Dolastatin 10 Derivative; (2S)-2-[(2S,3R)-3-[(2S,3R)-3-[(2S)-2-[(2R)-2-[(2S,3R)-3-[(2S)-2-[(2R)-2-[(2S,3R)-3-[(2S)-2-Amino-3-methylbutanamido]-3-methoxy-2-methylpropanamido]-3-phenylpropanamido]-3-methylbutanamido]-3-methoxy-2-methylpropanamido]-3-phenylpropanamido]-3-methoxy-2-methylpropanamido]-N,3-dimethylbutanamido]-4-methylpentanoic acid; MMAF precursor; ADC cytotoxin payload F
EINECS	Contact for details

Quality Control

Our Auristatin F is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and specifications are designed to support regulatory filings for preclinical and clinical-stage programs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.