Description

4-Trifluoromethylbenzylsulfonyl Chloride is a high-value organosulfur building block characterized by its reactive sulfonyl chloride group and trifluoromethyl aromatic moiety. This compound is essential for the synthesis of sulfonamide derivatives, which are pivotal in modern pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, crop protection, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of sulfonamide-based drug candidates, including protease inhibitors, receptor antagonists, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that leverage the biological activity of the sulfonamide functional group.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and functionalized surfaces.
• Chemical Biology: Employed as a probe or labeling reagent in proteomics and bioconjugation strategies due to its electrophilic reactivity.
• Organic Synthesis: Versatile building block for introducing the 4-(trifluoromethyl)benzylsulfonyl moiety into complex molecular architectures.

Basic Information

Product Name	4-Trifluoromethylbenzylsulfonyl Chloride
CAS No.	163295-75-8
Molecular Formula	C8H6ClF3O2S
Molecular Weight	258.65 g/mol
Synonyms	α-(Chlorosulfonyl)-4-(trifluoromethyl)benzene; 4-(Trifluoromethyl)benzylsulfonyl chloride; 1-(Chlorosulfonylmethyl)-4-(trifluoromethyl)benzene; (4-Trifluoromethylphenyl)methanesulfonyl chloride; p-Trifluoromethylbenzylsulfonyl chloride; 4-(Trifluoromethyl)benzenemethanesulfonyl chloride; α-Toluenesulfonyl chloride, α,α,α-trifluoro-p-tolyl-
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylbenzylsulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.