Description

(3,5-Difluorophenyl)Methanesulfonyl Chloride is a high-purity organosulfur building block and reagent of significant importance in advanced organic synthesis. Its core value lies in its dual functionality, serving as a versatile sulfonylation agent and a key precursor for introducing the (3,5-difluorophenyl)methanesulfonyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the difluorophenyl group for enhanced biological activity and metabolic stability.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials where sulfonamide linkages or specific fluorinated aromatic structures are required.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling studies.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects, enabling the production of bespoke sulfonamides and sulfonate esters for various R&D programs.

Basic Information

Item	Detail
Product Name	(3,5-Difluorophenyl)Methanesulfonyl Chloride
CAS No.	163295-74-7
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	3,5-Difluorophenylmethanesulfonyl chloride; 1-(Chlorosulfonyl)methyl-3,5-difluorobenzene; (3,5-Difluorobenzyl)sulfonyl chloride; α-Chlorosulfonyl-3,5-difluorotoluene; Mesyl chloride, (3,5-difluorophenyl)-; 3,5-Difluorobenzylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (3,5-Difluorophenyl)Methanesulfonyl Chloride is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards, and comprehensive analytical testing is performed to guarantee identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specification results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.