Description

Inecalcitol is a synthetic vitamin D3 analog with significant biological activity. This compound is a key intermediate and active pharmaceutical ingredient (API) in the research and development of novel therapeutics targeting vitamin D receptor pathways. It is primarily utilized by pharmaceutical companies and research institutions focused on oncology, dermatology, and metabolic disorders. The product is supplied under stringent quality controls to ensure consistency for critical R&D and manufacturing processes.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced vitamin D analogs and related pharmaceutical compounds.
• Active Pharmaceutical Ingredient (API): Used in the formulation of investigational drugs targeting conditions modulated by vitamin D receptors.
• Biochemical Research: A vital tool for studying vitamin D receptor (VDR) signaling, gene regulation, and cell differentiation mechanisms in vitro.
• Oncology Research: Investigated for its potential anti-proliferative and pro-differentiation effects in various cancer cell line studies.
• Dermatology R&D: Explored for applications in treating psoriasis and other skin disorders related to keratinocyte proliferation.
• Metabolic Disorder Studies: Used in research models for conditions like osteoporosis and secondary hyperparathyroidism.

Basic Information

Product Name	Inecalcitol
CAS No.	163217-09-2
Molecular Formula	C₂₉H₄₄O₃
Molecular Weight	440.66 g/mol
Synonyms	1α,25-Dihydroxy-22,23-didehydro-19-norvitamin D3; 19-Nor-1α,25-dihydroxyvitamin D2; TX 522; Inecalcitol (TX522); (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-hydroxy-1-methylhex-2-en-1-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our Inecalcitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.