Description

20',20'-Difluoro-4'-Deoxyvinblastine is a semi-synthetic derivative of the potent antimitotic agent vinblastine, modified to enhance its pharmacological profile and stability. This compound matters as a critical intermediate in advanced pharmaceutical research, particularly in the development of next-generation anticancer therapeutics and antibody-drug conjugates (ADCs). It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers focused on oncology drug discovery and high-potency active pharmaceutical ingredient (HPAPI) synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel vinca alkaloid derivatives for cancer therapy.
• Antibody-Drug Conjugate (ADC) Payload: Serves as a potent cytotoxic warhead for conjugation to monoclonal antibodies, enabling targeted cancer cell destruction.
• Oncology Research: Used in biochemical and cellular assays to study microtubule dynamics, mitotic arrest, and mechanisms of drug resistance.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, and NMR for quality control and method development in pharmaceutical manufacturing.
• Medicinal Chemistry: A scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Preclinical Development: Utilized in formulation studies and in vivo efficacy models to evaluate new chemotherapeutic candidates.

Basic Information

Product Name	20',20'-Difluoro-4'-Deoxyvinblastine
CAS No.	162652-96-2
Molecular Formula	C46H56F2N4O8
Molecular Weight	830.96 g/mol
Synonyms	4'-Deoxy-20',20'-difluorovinblastine; 20',20'-Difluoro-4'-deoxyvinblastine; 4'-Deoxy-20',20'-difluoro-vinblastine; Vinblastine, 20',20'-difluoro-4'-deoxy-; 20',20'-Difluoro-4'-deoxy-vinblastine; Difluorodeoxyvinblastine
EINECS	Contact for details

Quality Control

Our 20',20'-Difluoro-4'-Deoxyvinblastine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.