Description

Vinflunine is a third-generation, semi-synthetic vinca alkaloid derived from vinorelbine, representing a significant advancement in microtubule-targeting chemotherapy. Its primary value lies in its potent antimitotic activity, which disrupts microtubule dynamics and induces apoptosis in rapidly dividing cells. This makes it a critical active pharmaceutical ingredient (API) for the development of advanced oncology therapeutics, particularly for research and formulation targeting urothelial carcinoma and other solid tumors.

Application

• Oncological Pharmaceutical Development: As a key active pharmaceutical ingredient (API) in the formulation of injectable chemotherapeutic drugs.
• Clinical Research: For preclinical and clinical studies investigating novel cancer treatment regimens, especially for bladder and breast cancers.
• Anticancer Mechanism Studies: Used in biochemical and cellular research to study microtubule inhibition, cell cycle arrest, and apoptosis pathways.
• Drug Combination Research: Exploration of synergistic effects with other chemotherapeutic agents or targeted therapies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and pharmacokinetic studies in pharmaceutical manufacturing.
• Advanced Formulation Science: Development of liposomal, nanoparticle, or other novel drug delivery systems to improve therapeutic index and reduce side effects.

Basic Information

Product Name	Vinflunine
CAS No.	162652-95-1
Molecular Formula	C45H54F2N4O8
Molecular Weight	816.94 g/mol
Synonyms	Vinflunine Ditartrate; BMS-710485; 20',20'-Difluoro-3',4'-dihydrovinorelbine; 20',20'-Difluoro-3',4'-dihydro-5'-norvincaleukoblastine; (3'R,4'S)-20',20'-Difluoro-3',4'-dihydrovinorelbine; Javlor (brand name); 20,20-Difluoro-3,4-dihydrovinorelbine
EINECS	Contact for details

Quality Control

Our Vinflunine is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.