Description

tert-Butyl 4-(Chlorosulfonyl)Piperazine-1-Carboxylate is a high-value, multi-functional piperazine derivative and a key synthetic intermediate in advanced organic chemistry. Its core value proposition lies in its dual reactive sites—the chlorosulfonyl group and the Boc-protected amine—which enable efficient, sequential functionalization for building complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals requiring a piperazine scaffold.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of central nervous system (CNS) drugs, antivirals, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate a sulfonamide or piperazine moiety.
• Custom Chemical Synthesis: Serves as a versatile precursor for contract research organizations (CROs) and CDMOs to create bespoke compounds for client projects.
• Sulfonamide Library Development: Enables high-throughput parallel synthesis for medicinal chemistry teams creating diverse libraries of sulfonamide-based compounds for screening.
• Polymer Chemistry: Can be utilized as a monomer or cross-linking agent in the synthesis of specialty polymers with specific functional groups.
• Chemical Research & Development: Fundamental reagent in academic and industrial R&D for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	tert-Butyl 4-(Chlorosulfonyl)Piperazine-1-Carboxylate
CAS No.	162046-65-3
Molecular Formula	C9H17ClN2O4S
Molecular Weight	284.76 g/mol
Synonyms	1-Boc-4-(Chlorosulfonyl)piperazine; tert-Butyl 4-(Chlorosulfonyl)-1-piperazinecarboxylate; 4-(Chlorosulfonyl)-1-piperazinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(chlorosulfonyl)piperazine; Boc-4-(Chlorosulfonyl)piperazine; N-Boc-4-chlorosulfonylpiperazine; Piperazine-1-carboxylic acid tert-butyl ester 4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 4-(Chlorosulfonyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency meet the stringent requirements of our global clientele. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.